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Sunday 01st August 2010 01:01 AM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

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AstraZeneca Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence In situ Hybridization-Based Case-Control Study.
PURPOSE: We performed a study to determine if a fluorescence in situ...
Authors' Affiliations: Departments of Pathology, Epidemiology, Thoracic Clin Cancer Res. 2010 Jul 22.
DOI Direct Link
GlaxoSmithKline Medicines Research Centre 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
A pharmacophore model for triple reuptake inhibitors and the new class of...
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline J Med Chem. 2010 Jul 8;53(13):4989-5001.
DOI Direct Link
Forensic Science Service Body Fluids Conference jointly hosted by the Forensic Science Society & the Centre for Forensic Investigation, University of Teesside 18-19 April 2008 Convenors: Julie Allard and Brian Rankin.
The ASTM standards on Writing Ink Identification (ASTM 1789-04) and on...
The Forensic Science Service, Chorley Laboratory, Washington Hall, Euxton, Sci Justice. 2010 Jun;50(2):100-9. Epub 2010 Feb 8.
DOI Direct Link
Merck Sharp & Dohme Research Laboratories Topical delivery for the treatment of psoriasis.
Importance of the field: Psoriasis is one of the most common human skin...
Biopharmaceutics and Parenteral Delivery, Pharmaceutical Sciences, Merck Expert Opin Drug Deliv. 2010 Aug;7(8):977-92.
DOI Direct Link
Syngenta An aspartate to glycine change in the carboxyl transferase domain of acetyl CoA carboxylase and non-target-site mechanism(s) confer resistance to ACCase inhibitor herbicides in a Lolium multiflorum population.
BACKGROUND: The increasing use of ACCase-inhibiting herbicides has...
Syngenta, Jealott's Hill International Research Centre, Bracknell, Pest Manag Sci. 2010 Jul 20.
DOI Direct Link
AstraZeneca The application of HepRG cells in evaluation of cytochrome P450 induction properties of drug compounds.
The liver is the major organ metabolising drugs. The hepatocyte contains a...
Clinical Pharmacology and DMPK, AstraZeneca R&D, Molndal, Sweden. Methods Mol Biol. 2010;640:375-87.
DOI Direct Link
AstraZeneca 4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2).
A class of inhibitors of mitogen activated protein kinase-activated kinase...
Department of Biological Sciences, AstraZeneca R&D Lund, S-22187 Lund, Bioorg Med Chem Lett. 2010 Jun 25.
DOI Direct Link

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 7759557 Garden bean SB4285
Syngenta 7759550 Cauliflower plants having a long stem
GlaxoSmithKline 7759486 2,4,5-Trisubstituted pyrimidine compounds
GlaxoSmithKline 7759486 2,4,5-Trisubstituted pyrimidine compounds
AstraZeneca 7759328 Composition for inhalation
GlaxoSmithKline 7758866 Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
GlaxoSmithKline 7758866 Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
GlaxoSmithKline 7757333 Toothbrush
GlaxoSmithKline 7757333 Toothbrush
AstraZeneca 7754859 Targeted binding agents directed to PDGFR-alpha and uses thereof

Latest Genomics Publications:

Shaping the archaeal cell envelope.
Although archaea have a similar cellular organization as other ...
Ellen AF, Zolghadr B, Driessen AM, Albers SV,
http://dx.doi.org/10.1155/2010/608243
Archaea. 2010 Jul 7;2010:608243.
High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.
Here we describe a protocol for the identification of effectors of ...
Sergienko EA, Millan JL,
http://dx.doi.org/10.1038/nprot.2010.86
Nat Protoc. 2010 Aug;5(8):1431-9. Epub 2010 Jul 15.
Varietas: a functional variation database portal.
Current high-throughput technologies for investigating genomic variation ...
Paananen J, Ciszek R, Wong G,
http://dx.doi.org/10.1093/database/baq016
Database (Oxford). 2010 Jul 29;2010:baq016. Print 2010.
Early chordate origins of the vertebrate second heart field.
The vertebrate heart is formed from diverse embryonic territories, ...
Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L,
http://dx.doi.org/10.1126/science.1190181
Science. 2010 Jul 30;329(5991):565-8.
The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
Background: Multiple sclerosis outcome may be influenced by ultraviolet ...
Strange RC, Ramachandran S, Zeegers MP, Emes RD, Abraham R, Raveendran V, Boggild M, Gilford J, Hawkins CP,
http://dx.doi.org/10.1177/1352458510373784
Mult Scler. 2010 Jul 29.
The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease.
Peripheral T-cell lymphomas (PTCL) constitute a major treatment problem ...
Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M,
http://dx.doi.org/10.1158/0008-5472.CAN-08-3719
Cancer Res. 2010 Aug 1;70(15):6193-204.
Chagas disease: changes in knowledge and management.
More than 100 years after the discovery of human American trypanosomiasis ...
Lescure FX, Le Loup G, Freilij H, Develoux M, Paris L, Brutus L, Pialoux G,
http://dx.doi.org/10.1016/S1473-3099(10)70098-0
Lancet Infect Dis. 2010 Aug;10(8):556-570.
Erythrocyte membrane defects and asymmetry in paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome.
Paroxysmal nocturnal hemoglobinuria (PNH) and myelodysplastic syndromes ...
Basu S, Banerjee D, Ghosh M, Chakrabarti A,
http://dx.doi.org/10.1179/102453309X12583347114095
Hematology. 2010 Aug;15(4):236-9.
The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection.
ABSTRACT: There is a particular need for an effective vaccine against ...
Heckels JE, Williams JN,
http://dx.doi.org/10.1186/gm164
Genome Med. 2010 Jul 22;2(7):43.
Functional genomics and rheumatoid arthritis: where have we been and where should we go?
ABSTRACT: Studies in model organisms and humans have begun to reveal the ...
Jarvis JN, Frank MB,
http://dx.doi.org/10.1186/gm165
Genome Med. 2010 Jul 28;2(7):44.
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