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Thursday 03rd July 2008 11:25 PM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

Pubmed Logo
GlaxoSmithKline Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein:De-emphasizing the Geography of Binding (Relates to article by Redka, et al., Fast Forward 13 Jun 08).
The paper in this issue by Redka, Pisterzi and Wells illustrates some...
GlaxoSmithKline. Mol Pharmacol. 2008 Jun 26;.
DOI Direct Link
GlaxoSmithKline Drug discovery in the extracellular matrix.
The extracellular matrix (ECM) is an organised mesh of secreted proteins...
Computational Biology, Molecular Discovery Research, GlaxoSmithKline Drug Discov Today. 2008 Jun 24;.
DOI Direct Link
GlaxoSmithKline Pharmaceuticals Drug discovery in the extracellular matrix.
The extracellular matrix (ECM) is an organised mesh of secreted proteins...
Computational Biology, Molecular Discovery Research, GlaxoSmithKline Drug Discov Today. 2008 Jun 24;.
DOI Direct Link
GlaxoSmithKline Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein:De-emphasizing the Geography of Binding (Relates to article by Redka, et al., Fast Forward 13 Jun 08).
The paper in this issue by Redka, Pisterzi and Wells illustrates some...
GlaxoSmithKline. Mol Pharmacol. 2008 Jun 26;.
DOI Direct Link
GlaxoSmithKline Drug discovery in the extracellular matrix.
The extracellular matrix (ECM) is an organised mesh of secreted proteins...
Computational Biology, Molecular Discovery Research, GlaxoSmithKline Drug Discov Today. 2008 Jun 24;.
DOI Direct Link
Pfizer Global Research and Development Cardiovascular toxicity of minoxidil in the marmoset.
The aim of the experiments was to assess the toxicity of minoxidil, a...
Department of Toxicology and Comparative Medicine, Pfizer Global Research Toxicol Lett. 2008 Jun 5;.
DOI Direct Link
GSK A statistical assessment of QT data following placebo and moxifloxacin dosing in thorough QT studies.
The ICH guidelines indicate that a single "thorough QT study" should be...
Discovery Biometrics, GlaxoSmithKline, Harlow, Essex, UK. J Biopharm Stat. 2008;18(3):502-16.
DOI Direct Link

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 7390943 Inbred corn line G06-NP2598
AstraZeneca 7390908 Compounds effecting glucokinase
Biotica 7390895 Production of polyketides and other natural products
GSK 7388489 System and method for managing data on an RFID tag associated with a product
Syngenta 7388138 Inbred corn line G06-NP2608
Syngenta 7388136 Tomato plants
Syngenta 7388129 Soybean cultivar S06-WW152330
AstraZeneca 7388020 Benzimidazol derivatives modulate chemokine receptors
Cyclacel Limited 7388015 N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-N-phenylamines as antiproliferative compounds
GlaxoSmithKline 7384975 Substituted furochromenes, preparation thereof and their antiinflammatory action

Latest Genomics Publications:
Cloning and molecular characterization of a novel x-type glutenin gene Glu-D ( t ) 1 from Aegilops tauschii.
A novel gene encoding an x-type high molecular weight glutenin subunit ...
Fang J, Liu Y, Zhang C, Yang G, Li K, Shewry PR, He G,
http://dx.doi.org/10.1007/s11033-008-9297-1
Mol Biol Rep. 2008 Jul 2;.
ROLLED LEAF 9, encoding a GARP protein, regulates the leaf abaxial cell fate in rice.
Leaves, the collective organ produced by the shoot apical meristem (SAM), ...
Yan S, Yan CJ, Zeng XH, Yang YC, Fang YW, Tian CY, Sun YW, Cheng ZK, Gu MH,
http://dx.doi.org/10.1007/s11103-008-9365-x
Plant Mol Biol. 2008 Jul 2;.
Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse.
Syncoilin is a 64-kDa intermediate filament protein expressed in skeletal ...
McCullagh KJ, Edwards B, Kemp MW, Giles LC, Burgess M, Davies KE,
http://dx.doi.org/10.1007/s00335-008-9120-2
Mamm Genome. 2008 Jul 2;.
Transcriptome map for seedling stage specific salinity stress response indicates a specific set of genes as candidate for saline tolerance in Oryza sativa L.
Oryza sativa L. cv IR64 is a widely cultivated, salt-sensitive indica ...
Kumari S, Panjabi Nee Sabharwal V, Kushwaha HR, Sopory SK, Singla-Pareek SL, Pareek A,
http://dx.doi.org/10.1007/s10142-008-0088-5
Funct Integr Genomics. 2008 Jul 2;.
Escape from adaptive conflict after duplication in an anthocyanin pathway gene.
Gene duplications have been recognized as an important source of ...
Des Marais DL, Rausher MD,
http://dx.doi.org/10.1038/nature07092
Nature. 2008 Jun 25;.
The art of classifying renal allograft pathology.
This Practice Point commentary discusses Solez et al.'s most recent update ...
Weening JJ,
http://dx.doi.org/10.1038/ncpneph0859
Nat Clin Pract Nephrol. 2008 Jul 1;.
Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.
Breast cancer is a heterogeneous disease with distinct molecular subtypes ...
O'Brien C, Cavet G, Pandita A, Hu X, Haydu L, Mohan S, Toy K, Rivers CS, Modrusan Z, Amler LC, Lackner MR,
http://dx.doi.org/10.1158/0008-5472.CAN-08-0234
Cancer Res. 2008 Jul 1;68(13):5380-9.
Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.
Defective mismatch repair (MMR) in humans causes hereditary nonpolyposis ...
Feitsma H, Kuiper RV, Korving J, Nijman IJ, Cuppen E,
http://dx.doi.org/10.1158/0008-5472.CAN-08-0019
Cancer Res. 2008 Jul 1;68(13):5059-66.
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.
The genome of a subset of non-small-cell lung cancers (NSCLC) harbors a ...
Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H,
http://dx.doi.org/10.1158/0008-5472.CAN-07-6158
Cancer Res. 2008 Jul 1;68(13):4971-6.
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.
Context: Vitamin D deficiency is associated with many adverse health ...
Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM,
http://dx.doi.org/10.1210/jc.2007-2702
J Clin Endocrinol Metab. 2008 Jul 1;.
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