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Saturday 28th January 2012 02:19 PM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

Pubmed Logo
GlaxoSmithKline Targeting phosphoinositide 3-kinase delta for allergic asthma.
Chronic inflammation in the lung has long been linked to the pathogenesis...
*Biological Reagents and Assay Development, Platform Technology and Biochem Soc Trans. 2012 Feb 1;40(1):240-5.
DOI Direct Link
GlaxoSmithKline Pharmaceuticals Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1.
The ion channel TRPA1 is activated by a wide variety of noxious stimuli,...
Neuronal Targets DPU, Respiratory Therapy Area Unit, GlaxoSmithKline Neurosci Lett. 2011 Oct 10;503(3):157-62. Epub 2011 Aug 10.
DOI Direct Link
GlaxoSmithKline Targeting phosphoinositide 3-kinase delta for allergic asthma.
Chronic inflammation in the lung has long been linked to the pathogenesis...
*Biological Reagents and Assay Development, Platform Technology and Biochem Soc Trans. 2012 Feb 1;40(1):240-5.
DOI Direct Link
Syngenta Direct prediction of bioethanol yield in sugar beet pulp using near infrared spectroscopy.
Sugar beets are a raw material for the production of sugar and ethanol....
Syngenta Seeds S.A., Barcelona 08006, Spain. Bioresour Technol. 2011 Oct;102(20):9542-9. Epub 2011 Aug 4.
DOI Direct Link
AstraZeneca Preoperative blood transfusions for sickle cell disease.
BACKGROUND: Sickle cell disease is one of the most common inherited...
AstraZeneca, Parklands (90HW2Q1), Alderley Park, Cheshire, UK, SK10 4TG. Cochrane Database Syst Rev. 2012 Jan 18;1:CD003149.
DOI Direct Link
GlaxoSmithKline Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children.
Aim: to assess whether an adaptive design in early clinical trials based...
LACDR, Division of Pharmacology, Leiden University, The Netherlands Br J Clin Pharmacol. 2012 Jan 18. doi: 10.1111/j.1365-2125.2012.04187.x.
DOI Direct Link
GlaxoSmithKline Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children.
Aim: to assess whether an adaptive design in early clinical trials based...
LACDR, Division of Pharmacology, Leiden University, The Netherlands Br J Clin Pharmacol. 2012 Jan 18. doi: 10.1111/j.1365-2125.2012.04187.x.
DOI Direct Link

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 8097777 Soybean cultivar 05RM310021
Syngenta 8097774 Cytochrome P450 genes conferring herbicide resistance
Syngenta 8097631 Fungicidal composition comprising cyprodinil
GlaxoSmithKline 8097626 IL-8 receptor antagonists
GlaxoSmithKline 8097626 IL-8 receptor antagonists
GlaxoSmithKline 8097618 Pyridine derivatives and their use in the treatment of psychotic disorders
GlaxoSmithKline 8097618 Pyridine derivatives and their use in the treatment of psychotic disorders
Syngenta 8097561 Herbicidal composition
GlaxoSmithKline 8097281 Composition
GlaxoSmithKline 8097281 Composition

Latest Genomics Publications:
GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy.
OBJECTIVE:The idiopathic generalized epilepsies (IGE) are the most common ...
Striano P, Weber YG, Toliat MR, Schubert J, Leu C, Chaimana R, Baulac S, Guerrero R, Leguern E, Lehesjoki AE, Polvi A, Robbiano A, Serratosa JM, Guerrini R, Nurnberg P, Sander T, Zara F, Lerche H, Marini C,
http://dx.doi.org/10.1212/WNL.0b013e318247ff54
Neurology. 2012 Jan 25.
Discovery of Pyrobaculum small RNA families with atypical pseudouridine guide RNA features.
In the Eukarya and Archaea, small RNA-guided pseudouridine modification is ...
Bernick DL, Dennis PP, Hochsmann M, Lowe TM,
http://dx.doi.org/10.1261/rna.031385.111
RNA. 2012 Jan 26.
Complete Genome Sequences of 138 Mycobacteriophages.
Bacteriophages are the most numerous biological entities in the biosphere, ...
Hatfull GF,
http://dx.doi.org/10.1128/JVI.06870-11
J Virol. 2012 Feb;86(4):2382-2384.
Inter-chromosomal level of genome organization and longevity-related phenotypes in humans.
Studies focusing on unraveling the genetic origin of health span in humans ...
Kulminski AM, Culminskaya I, Yashin AI,
http://dx.doi.org/10.1007/s11357-011-9374-6
Age (Dordr). 2012 Jan 27.
Population biobanking in selected European countries and proposed model for a Polish national DNA bank.
Population biobanks offer new opportunities for public health, are ...
Sak J, Pawlikowski J, Goniewicz M, Witt M,
http://dx.doi.org/10.1007/s13353-012-0082-4
J Appl Genet. 2012 Jan 27.
Genomics of endangered primates. Bahcall O,
http://dx.doi.org/10.1038/ng.1096
Nat Genet. 2012 Jan 27;44(2):120. doi: 10.1038/ng.1096.
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug ...
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R,
http://dx.doi.org/10.1038/nature10868
Nature. 2012 Jan 26. doi: 10.1038/nature10868.
"US-JAPAN CONFERENCE: INFLAMMATION, DIABETES AND CANCER" held at the Beckman Research Institute of City of Hope, Duarte, CA, USA.
The conference was held to facilitate research collaborations between US ...
Fujita-Yamaguchi Y, Lin RJ, Jove R,
Biosci Trends. 2011 Dec;5(6):277-80.
Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.
The hedgehog (Hh) signaling pathway is involved in numerous developmental ...
McNeill B, Perez-Iratxeta C, Mazerolle C, Furimsky M, Mishina Y, Andrade-Navarro MA, Wallace VA,
http://dx.doi.org/10.1016/j.mcn.2011.12.008
Mol Cell Neurosci. 2012 Jan 16.
Genomic associations with somatic cell score in first-lactation Holstein cows.
This genome-wide association study aimed to identify loci associated with ...
Wijga S, Bastiaansen JW, Wall E, Strandberg E, de Haas Y, Giblin L, Bovenhuis H,
http://dx.doi.org/10.3168/jds.2011-4717
J Dairy Sci. 2012 Feb;95(2):899-908.
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