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Thursday 18th March 2010 03:14 AM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

Pubmed Logo
GlaxoSmithKline Stem cells for heart failure in the aging heart.
Despite a wide range of therapeutic interventions, the prognosis for most...
Heart Failure Discovery Performance Unit, Metabolic Pathways Center of Heart Fail Rev. 2010 Mar 12.
DOI Direct Link
Merck Sharp & Dohme Research Laboratories Level of awareness about osteoporosis among women 50 years and older in Puerto Rico.
Osteoporosis is an established and well-defined disease that affects...
Medical Department, Merck Sharp & Dohme (I.A.) Corp., Carolina, Puerto P R Health Sci J. 2010 Mar;29(1):54-9.
GlaxoSmithKline Stem cells for heart failure in the aging heart.
Despite a wide range of therapeutic interventions, the prognosis for most...
Heart Failure Discovery Performance Unit, Metabolic Pathways Center of Heart Fail Rev. 2010 Mar 12.
DOI Direct Link
Pfizer Global Research and Development Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation.
INTRODUCTION: The effects of angiotensin (Ang) IV result from binding to a...
Pfizer Global Research and Development CN8000, Princeton, NJ, 08543-8000, Psychopharmacology (Berl). 2010 Mar 12.
DOI Direct Link
GSK Formulation considerations for developing toothpastes suitable for those at risk from erosive tooth wear.
The following viewpoint from PSI and EFSPI regarding the current level of...
GlaxoSmithKline Consumer Healthcare Weybridge, Surrey, UK. J Clin Dent. 2009;20(6):199-202.
GSK Evaluation of different fluoridated dentifrice formulations using an in situ erosion remineralization model.
OBJECTIVE: The objective of these three clinical in situ studies was to...
GlaxoSmithKline Consumer Healthcare Weybridge, Surrey, UK. J Clin Dent. 2009;20(6):192-8.
GSK Fluoride penetration from toothpastes into incipient enamel erosive lesions investigated using dynamic secondary ion mass spectrometry.
OBJECTIVE: The primary aim of this study was to assess the utility of...
GlaxoSmithKline Consumer Healthcare, Weybridge, UK. J Clin Dent. 2009;20(6):186-91.

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 7674893 Promoters for regulation of gene expression in plant roots
GlaxoSmithKline 7674887 Thrombopoietin mimetics
GlaxoSmithKline 7674887 Thrombopoietin mimetics
AstraZeneca 7674801 Alkyl urea substituted pyridines
GlaxoSmithKline 7674792 5(Z)-5-(6-quinoxalinylmethylidene)-2-[2,6-dichlorophenyl)amino]-1,3-thiazo- l-4(5H)-one
GlaxoSmithKline 7674792 5(Z)-5-(6-quinoxalinylmethylidene)-2-[2,6-dichlorophenyl)amino]-1,3-thiazo- l-4(5H)-one
Waters Corporation 7674375 Closed loop flow control of a HPLC constant flow pump to enable low-flow operation
Syngenta 7671257 Inbred corn line G07-NPDI4214
AstraZeneca 7671195 Process for preparing dibenzothiazepine compounds
AstraZeneca 7671060 Heteroaryl benzamide derivatives

Latest Genomics Publications:
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.
Common genetic variations in genes involved in DNA repair or response to ...
Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ,
http://dx.doi.org/10.1002/ijc.25318
Int J Cancer. 2010 Mar 15.
Finding the middle ground: how kinetochores power chromosome congression.
Genomic stability requires error-free chromosome segregation during ...
Kops GJ, Saurin AT, Meraldi P,
http://dx.doi.org/10.1007/s00018-010-0321-y
Cell Mol Life Sci. 2010 Mar 16.
Genome-wide analysis of primary auxin-responsive Aux/IAA gene family in maize (Zea mays. L.).
The phytohormone auxin is important in various aspects of organism growth ...
Wang Y, Deng D, Bian Y, Lv Y, Xie Q,
http://dx.doi.org/10.1007/s11033-010-0058-6
Mol Biol Rep. 2010 Mar 16.
Association of TGFB1 -509 C>T polymorphism with breast cancer: evidence from a meta-analysis involving 23,579 subjects.
Although a number of genetic studies have attempted to link transforming ...
Niu W, Qi Y, Gao P, Zhu D,
http://dx.doi.org/10.1007/s10549-010-0832-0
Breast Cancer Res Treat. 2010 Mar 16.
AtBAG7, an Arabidopsis Bcl-2-associated athanogene, resides in the endoplasmic reticulum and is involved in the unfolded protein response.
The Bcl-2-associated athanogene (BAG) family is an evolutionarily ...
Williams B, Kabbage M, Britt R, Dickman MB,
http://dx.doi.org/10.1073/pnas.0912670107
Proc Natl Acad Sci U S A. 2010 Mar 15.
Induction of TGF-{beta}1 and TGF-{beta}1-dependent predominant Th17 differentiation by group A streptococcal infection.
Recurrent group A Streptococcus (GAS) tonsillitis and associated ...
Wang B, Dileepan T, Briscoe S, Hyland KA, Kang J, Khoruts A, Cleary PP,
http://dx.doi.org/10.1073/pnas.0904831107
Proc Natl Acad Sci U S A. 2010 Mar 15.
Streptococcus mutans serine/threonine kinase PknB regulates competence development, bacteriocin production and cell-wall metabolism.
Bacteria can detect, transmit and react to signals from the outside world ...
Banu LD, Conrads G, Rehrauer H, Hussain H, Allan E, van der Ploeg JR,
http://dx.doi.org/10.1128/IAI.01167-09
Infect Immun. 2010 Mar 15.
Gene network visualization and quantitative synteny analysis of more than 300 marine T4-like phage scaffolds from the GOS metagenome.
Bacteriophages (phages) are the most abundant biological entities in the ...
Comeau AM, Arbiol C, Krisch HM,
http://dx.doi.org/10.1093/molbev/msq076
Mol Biol Evol. 2010 Mar 15.
Risk Factor Profiles for Atherosclerotic Cardiovascular Disease in Black and Other Africans with Established Rheumatoid Arthritis.
OBJECTIVE: Black Africans reportedly experience a distinctly low risk for ...
Solomon A, Christian BF, Norton GR, Woodiwiss AJ, Dessein PH,
http://dx.doi.org/10.3899/jrheum.091032
J Rheumatol. 2010 Mar 15.
Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes.
ABSTRACT: BACKGROUND: Structured noncoding RNAs perform many functions ...
Weinberg Z, Wang JX, Bogue J, Yang J, Corbino K, Moy RH, Breaker RR,
http://dx.doi.org/10.1186/gb-2010-11-3-r31
Genome Biol. 2010 Mar 15;11(3):R31.
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