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The use of gene array technology and proteomics in the search of new targets of diseases for therapeutics.
The advent of functional genomics has been greatly broadening our view and ...
Ferrer-Alcon M, Arteta D, Guerrero MJ, Fernandez-Orth D, Simon L, Martinez A,
http://dx.doi.org/10.1016/j.toxlet.2008.10.014
Toxicol Lett. 2008 Oct 28.
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Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.
OBJECTIVES: We aimed to determine whether the common variation at the ...
Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT,
http://dx.doi.org/10.1016/j.jacc.2008.07.047
J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81.
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Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer.
The search for target genes involved in unbalanced acquired chromosomal ...
An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Hall AG, Harrison CJ, Irving JA, Strefford JC,
http://dx.doi.org/10.1073/pnas.0803494105
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17050-4. Epub 2008 Oct 28.
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Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results from Two Prospective Cohorts.
Objective: To investigate the role of circulating resistin levels in the ...
Chen BH, Song Y, Ding EL, Roberts CK, Manson JE, Rifai N, Buring JE, Gaziano JM, Liu S,
http://dx.doi.org/10.2337/dc08-1625
Diabetes Care. 2008 Oct 28.
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ATP/ADP Binding to a Novel Nucleotide Binding Domain of the Reticulocyte-binding Protein Py235 of Plasmodium yoelii.
The mechanism by which a malaria merozoite recognizes a suitable host cell ...
Ramalingam JK, Hunke C, Gao X, Gruber G, Preiser PR,
http://dx.doi.org/10.1074/jbc.M803102200
J Biol Chem. 2008 Dec 26;283(52):36386-96. Epub 2008 Oct 28.
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MetaMine - A tool to detect and analyse gene patterns in their environmental context.
ABSTRACT: BACKGROUND: Modern sequencing technologies allow rapid ...
Bohnebeck U, Lombardot T, Kottmann R, Glockner FO,
http://dx.doi.org/10.1186/1471-2105-9-459
BMC Bioinformatics. 2008 Oct 28;9(1):459.
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Transcriptome profiling in crustaceans as a tool for ecotoxicogenomics: Daphnia magna DNA microarray.
Chemicals released into the environment have the potential to affect ...
Watanabe H, Kobayashi K, Kato Y, Oda S, Abe R, Tatarazako N, Iguchi T,
http://dx.doi.org/10.1007/s10565-008-9108-4
Cell Biol Toxicol. 2008 Dec;24(6):641-7. Epub 2008 Oct 28.
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Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC.
The proteome of any system is a dynamic entity, such that the ...
Doherty MK, Hammond DE, Clague MJ, Gaskell SJ, Beynon RJ,
http://dx.doi.org/10.1021/pr800641v
J Proteome Res. 2008 Oct 28.
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Evolutionary redefinition of immunoglobulin light chain isotypes in tetrapods using molecular markers.
The phylogenetic relationships of Ig light chain (IGL) genes are difficult ...
Das S, Nikolaidis N, Klein J, Nei M,
http://dx.doi.org/10.1073/pnas.0808800105
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16647-52. Epub 2008 Oct 21.
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