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Recent Publications by Cyclacel Limited: |  | |
| Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.
The main difficulty in the development of ATP antagonist kinase inhibitors... | Cyclacel Limited, Dundee DD15JJ, Scotland, UK. | Chem Biol. 2010 Oct 29;17(10):1111-21.
DOI Direct Link |
| REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors.
We describe a drug-design strategy termed REPLACE (REplacement with... | Cyclacel Limited, James Lindsay Place, Dundee, DD1 5JJ, UK. | Chembiochem. 2006 Dec;7(12):1909-15.
DOI Direct Link |
| Recent progress in the discovery and development of cyclin-dependent kinase inhibitors.
Cyclin-dependent kinases (CDKs) have long been known to be the main... | Cyclacel Limited, James Lindsay Place, Dundee DD1 5JJ, Scotland, UK. | Expert Opin Investig Drugs. 2005 Apr;14(4):457-77.
DOI Direct Link |
| Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin.
Synthesis of paclitaxel-penetratin (pAntp) constructs, in which the 2'- or... | Cyclacel Limited, James Lindsay Place, Dundee DD1 5JJ, Scotland, UK. | Bioorg Med Chem Lett. 2006 May 15;16(10):2628-31. Epub 2006 Mar 2.
DOI Direct Link |
| Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Inhibition of cyclin A- and cyclin E-associated cyclin-dependent kinase-2... | Cyclacel Limited, James Lindsay Place, Dundee, Scotland, UK. | Org Biomol Chem. 2004 Oct 7;2(19):2735-41. Epub 2004 Sep 9.
DOI Direct Link |
Cyclacel Limited Patents: |  |
| US Patent No. | Title |
| 7902361 | Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy |
| 6992169 | Carrier based drug delivery system |
| 6972198 | Methods and compositions using protein binding partners |
| 6972182 | Methods and compositions using coiled binding partners |
| 6962792 | Methods and means for inhibition of Cdk4 activity |