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Recent Publications by De Novo Pharmaceuticals Ltd.: |  | |
| De novo ligand design to partially flexible active sites: application of the ReFlex algorithm to carboxypeptidase A, acetylcholinesterase, and the estrogen receptor.
Reflex is a recent algorithm in the de novo ligand design software,... | De Novo Pharmaceuticals Ltd., Compass House, Vision Park, Chivers Way, | J Chem Inf Model. 2008 Feb;48(2):296-305. Epub 2008 Jan 31.
DOI Direct Link |
| Chemical genomics: a challenge for de novo drug design.
De novo design provides an in silico toolkit for the design of novel small... | De Novo Pharmaceuticals Ltd., Vision Park, Compass House, Histon, | Mol Biotechnol. 2007 Nov;37(3):237-45. Epub 2007 Jun 30.
DOI Direct Link |
| Generation and selection of novel estrogen receptor ligands using the de novo structure-based design tool, SkelGen.
A de novo design approach to generating novel estrogen receptor (ER)... | De Novo Pharmaceuticals Ltd., Compass House, Vision Park, Histon, | J Chem Inf Model. 2006 Mar-Apr;46(2):642-7.
DOI Direct Link |
| De novo ligand design to an ensemble of protein structures.
We describe a combinatorial method for de novo ligand design to an... | De Novo Pharmaceuticals Ltd., Compass House, Cambridge, United Kingdom. | Proteins. 2006 Jul 1;64(1):43-59.
DOI Direct Link |
| Exhaustive de novo design of low-molecular-weight fragments against the ATP-binding site of DNA-gyrase.
We present a de novo design approach to generating small fragments in the... | De Novo Pharmaceuticals Ltd., Compass House, Vision Park, Histon, | J Chem Inf Model. 2006 May-Jun;46(3):1168-73.
DOI Direct Link |
De Novo Pharmaceuticals Ltd. Patents: |  |
| US Patent No. | Title |
| 7323596 | Antimicrobial agents |
| 7241921 | Bacterial enzyme inhibitors |