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Recent Publications by Merck Sharp and Dohme Research Laboratories: |  | |
| High-throughput microsomal stability assay for screening new chemical entities in drug discovery.
In this work, the authors present a novel, robotic, automated protocol for... | Department of DMPK, Istituto di Ricerche di Biologia Molecolare P. | J Biomol Screen. 2008 Oct;13(9):862-9. Epub 2008 Sep 23.
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| Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
Bridgehead substituted derivatives of bicyclo[4.2.1]nonanes were... | Department of Medicinal Chemistry, Merck Sharp and Dohme Research | Bioorg Med Chem Lett. 2008 Jan 1;18(1):375-9. Epub 2007 Oct 22.
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| Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
The in vivo occupancy of brain benzodiazepine binding sites by compounds A... | Department of Medicinal Chemistry, Merck Sharp and Dohme Research | Biopharm Drug Dispos. 2007 Sep;28(6):275-82.
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| Development of a simple and reliable accurate mass liquid chromatography/electrospray ionization mass spectrometry method for high-resolution accurate mass determinations of new drug entities on a triple quadrupole mass spectrometer.
Accurate mass measurements are used to determine the elemental composition... | Department of Drug Metabolism and Pharmacokinetics, Istituto di Ricerche | Rapid Commun Mass Spectrom. 2007;21(18):3051-9.
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| A practical synthesis of a gamma-secretase inhibitor.
A practical and scaleable synthesis of the gamma-secretase inhibitor 1 is... | Department of Process Research, Merck Sharp and Dohme Research | J Org Chem. 2007 May 25;72(11):4149-55. Epub 2007 Apr 28.
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