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Recent Publications by Merck Sharp and Dohme Research Laboratories: |  | |
| Turbulent flow chromatography TFC-tandem mass spectrometry supporting in vitro/vivo studies of NCEs in high throughput fashion.
Turbulent Flow Chromatography (TFC) is a powerful approach for on-line... | Department of Drug Metabolism and Pharmacokinetics, Istituto di Ricerche | J Pharm Biomed Anal. 2010 Mar 11;51(4):834-41. Epub 2009 Oct 12.
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| A novel approach to 3-methylindoles by a Heck/cyclization/isomerization process.
A novel synthesis of 3-methylindoles from chlorotriflates through a Heck... | Department of Process Research, Merck Sharp and Dohme Research | Org Lett. 2010 Feb 19;12(4):668-71.
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| The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates.
BACKGROUND AND PURPOSE: alpha5IA... | Merck Sharp and Dohme Research Laboratories, The Neuroscience Research | Br J Pharmacol. 2009 Jul;157(5):796-803. Epub 2009 Apr 30.
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| High-throughput microsomal stability assay for screening new chemical entities in drug discovery.
In this work, the authors present a novel, robotic, automated protocol for... | Department of DMPK, Istituto di Ricerche di Biologia Molecolare P. | J Biomol Screen. 2008 Oct;13(9):862-9. Epub 2008 Sep 23.
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| Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
Bridgehead substituted derivatives of bicyclo[4.2.1]nonanes were... | Department of Medicinal Chemistry, Merck Sharp and Dohme Research | Bioorg Med Chem Lett. 2008 Jan 1;18(1):375-9. Epub 2007 Oct 22.
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