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Recent Publications by GlaxoSmithKline Medicines Research Centre: |  | |
| Synthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists.
To identify new CRF 1 receptor antagonists, an attempt to modify the... | Neurosciences Centre of Excellence for Drug Discovery and Molecular | J Med Chem. 2008 Nov 7.
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| Oesophageal afferent pathway sensitivity in non-erosive reflux disease.
Patients with non-erosive reflux disease (NERD) report symptoms which... | Immuno-inflammation CEDD, GlaxoSmithKline Medicines Research Centre, | Neurogastroenterol Motil. 2008 Aug;20(8):877-83. Epub 2008 Apr 9.
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| The CB1 receptor antagonist, SR141716A, prevents high-frequency stimulation-induced reduction of feedback inhibition in the rat dentate gyrus following perforant path stimulation in vivo.
Endocannabinoids acting through CB(1) receptors are thought to regulate... | Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicines Research | Brain Res. 2008 Aug 5;1223:50-8. Epub 2008 Jun 5.
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| Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine.
Acute administration of NMDA receptor (NMDAR) antagonists such as... | Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicines Research | Neuropsychopharmacology. 2008 Jun;33(7):1690-703. Epub 2007 Sep 5.
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| Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat.
RATIONALE: Increasing experimental evidence suggests that impaired... | Biology, Neurosciences CEDD, GlaxoSmithKline Medicines Research Centre, | Psychopharmacology (Berl). 2008 Aug 15.
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