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Recent Publications by GlaxoSmithKline Medicines Research Centre: |  | |
| Lead-oriented synthesis: a new opportunity for synthetic chemistry.
The pharmaceutical industry remains solely reliant on synthetic chemistry... | GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, | Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1114-22. doi:
DOI Direct Link |
| GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs.
Ghrelin is a 28-amino-acid polypeptide expressed in the stomach and... | GlaxoSmithKline Medicines Research Centre, Verona, Italy. | Neuroendocrinology. 2011;94(2):158-68. Epub 2011 Jul 22.
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| Method ruggedness studies incorporating a risk based approach: a tutorial.
This tutorial explains how well thought-out application of design and... | Product Development and Statistical Sciences, GlaxoSmithKline Medicines | Anal Chim Acta. 2011 Oct 10;703(2):101-13. Epub 2011 Jul 19.
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| The discovery of long-acting saligenin beta adrenergic receptor agonists incorporating hydantoin or uracil rings.
A series of novel, potent and selective human beta(2) adrenoceptor... | Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research | Bioorg Med Chem. 2011 Jul 15;19(14):4192-201. Epub 2011 Jun 21.
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| Computer-aided molecular design under the SWOTlight.
The pharmaceutical industry remains solely reliant on synthetic chemistry... | GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, | J Comput Aided Mol Des. 2012 Jan;26(1):51-6. Epub 2011 Dec 15.
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