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Recent Publications by GlaxoSmithKline Medicines Research Centre: |  | |
| 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
A pharmacophore model for triple reuptake inhibitors and the new class of... | Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline | J Med Chem. 2010 Jul 8;53(13):4989-5001.
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| Identification of a sulfonamide series of CCR2 antagonists.
A series of sulfonamide CCR2 antagonists was identified by high-throughput... | GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage | Bioorg Med Chem Lett. 2010 May 7.
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| A multi-technique approach using LC-NMR, LC-MS, semi-preparative HPLC, HR-NMR and HR-MS for the isolation and characterization of low-level unknown impurities in GW876008, a novel corticotropin-release factor 1 antagonist.
A multi-technique approach was applied in order to fully characterize four... | Analytical Chemistry, GlaxoSmithKline Medicines Research Centre, Via | J Pharm Biomed Anal. 2010 Nov 2;53(3):517-25. Epub 2010 Jun 22.
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| Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high... | Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research | J Med Chem. 2010 Jun 10;53(11):4522-30.
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| A specific and direct comparison of the trifluoromethyl and pentafluoro sulfanyl groups on the selective dopamine D(3) antagonist 3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}pr opyl)-1-phenyl-3-azabicyclo[3.1.0]h
A direct and specific comparison of a trifluoromethyl group with the... | Neurosciences Centre of Excellence, GlaxoSmithKline Medicines Research | Bioorg Med Chem Lett. 2010 Aug 1;20(15):4566-8. Epub 2010 Jun 8.
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