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Recent Publications by Evotec UK: |  | |
| Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development.
Drug-induced liver injury (DILI) is a major cause of attrition during both... | Evotec (UK) Ltd. , Abingdon, Oxford , United Kingdom. | Drug Metab Rev. 2012 Feb;44(1):127-40.
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| Discovery and Structure-Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington's Disease.
Tissue transglutaminase 2 (TG2) is a multifunctional protein primarily... | Evotec (UK) Ltd. , 114 Milton Park, Abingdon, OX14 4SA, U.K. | J Med Chem. 2012 Jan 27.
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| Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase.
The inhibition of Aurora kinases in order to arrest mitosis and... | Evotec (UK) Ltd., 114 | J Med Chem. 2011 Jan 13;54(1):312-9. Epub 2010 Dec 3.
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| Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders.
The discovery of a novel series of 5-HT(2C) agonists based on a tricyclic... | Evotec UK Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, UK. | Bioorg Med Chem Lett. 2011 Jan 1;21(1):34-7. Epub 2010 Nov 24.
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| Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists.
A series of potent and subtype selective H3 receptor antagonists... | Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire, United Kingdom. | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5165-9.
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