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Recent Publications by AstraZeneca R&D: |  | |
| The significance of ambient-temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging.
RATIONALE: Mass spectrometry imaging has proven to be a complementary... | Medical Mass Spectrometry, Department of Pharmaceutical Biosciences, | Rapid Commun Mass Spectrom. 2012 Mar 15;26(5):494-8. doi:
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| Optimisation of DMPK by the Inhaled Route: Challenges and Approaches.
The renewed interest in inhalation delivery over recent years has led to... | Discovery DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, | Curr Drug Metab. 2012 Feb 2. |
| Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate- acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
A novel arylsulfonamide-containing series of compounds represented by 1,... | Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse | Bioorg Med Chem Lett. 2012 Jan 14.
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| gamma-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration.
An oral, peripherally restricted CB1/CB2 agonist could provide an... | Department of Medicinal Chemistry, AstraZeneca R&D Montreal, 7171 | Bioorg Med Chem Lett. 2012 Jan 4.
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| Crystal structures of the Chromobacterium violaceumomega-transaminase reveal major structural rearrangements upon binding of coenzyme PLP.
The bacterial omega-transaminase from Chromobacterium violaceum... | Division of Biochemistry, KTH Royal Institute of Technology, Stockholm, | FEBS J. 2012 Jan 23. doi: 10.1111/j.1742-4658.2012.08468.x.
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