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Recent Publications by Astex Technology Ltd: |  | |
| Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.
Since the discovery that activating mutations of the Ras GTPase were... | Astex Technology Ltd, 436 Cambridge Science Park, Milton Rd, Cambridge CB4 | Curr Opin Pharmacol. 2005 Aug;5(4):350-6.
DOI Direct Link |
| The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3).
Extensive SAR studies on the unselective BRS3 agonist,... | Astex | J Pept Sci. 2005 Mar;11(3):136-41.
DOI Direct Link |
| Virtual screening using protein-ligand docking: avoiding artificial enrichment.
This study addresses a number of topical issues around the use of... | Astex Technology Ltd., 436 Cambridge Science Park, Milton Road, Cambridge | J Chem Inf Comput Sci. 2004 May-Jun;44(3):793-806.
DOI Direct Link |
| High-throughput protein crystallography and drug discovery.
Single crystal X-ray diffraction is the technique of choice for studying... | Astex Technology Ltd., 436 Science Park, Milton Road, Cambridge, UK. | Chem Soc Rev. 2004 Oct 20;33(8):558-65. Epub 2004 Sep 20.
DOI Direct Link |
| Structure-guided fragment screening for lead discovery.
Fragment-based ligand screening can be a highly effective strategy for... | Astex Technology Ltd, 436 Cambridge Science Park, Milton Road, Cambridge, | Curr Opin Drug Discov Devel. 2004 Jul;7(4):404-10. |
Astex Technology Ltd Patents: |  |
| US Patent No. | Title |
| 6546074 | Protein crystal structure and method for identifying protein modulators |
| 6484103 | Crystal structure |