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Recent Publications by Oxagen Ltd.: |  | |
| Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.
It is now well established that interaction of PGD(2) with chemoattractant... | Oxagen | J Immunol. 2009 Jun 15;182(12):7580-6.
DOI Direct Link |
| Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.
The mechanisms by which immunologically activated mast cells stimulate the... | Clin Exp Immunol. 2009 Apr;156(1):126-33. Epub 2009 Feb 11.
DOI Direct Link |
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| Antagonists of the prostaglandin D2 receptor CRTH2.
Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and... | Pharmacology, Oxagen | Drug News Perspect. 2008 Jul-Aug;21(6):317-22.
DOI Direct Link |
| The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.
Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and... | Oxagen Ltd, 91 Milton | Br J Pharmacol. 2008 Mar;153 Suppl 1:S191-9. Epub 2007 Oct 29.
DOI Direct Link |
| A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.
Activation of human CRTH2(+) CD4(+) T helper type 2 (Th2) cells with... | Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom. | Immunology. 2007 Aug;121(4):577-84. Epub 2007 Apr 16.
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Oxagen Ltd. Patents: |  |
| US Patent No. | Title |
| 7750027 | Compounds having CRTH2 antagonist activity |
| 7582672 | Compounds for the treatment of CRTH2-mediated diseases and conditions |
| 7521194 | Method for detection of MIP-4 and CCRL2 binding and activity modulating agents |