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Recent Publications by GlaxoSmithKline Medicine Research Centre: |  | |
| Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze.
The involvement of Neuropeptide Y (NPY) in the pathophysiology of mood... | Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicine Research | Peptides. 2006 Dec;27(12):3202-7. Epub 2006 Sep 7.
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| 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists.
The discovery of new highly potent and selective dopamine D3 receptor... | Psychiatry Centre of Excellence, Molecular Discovery Research, and Safety | J Med Chem. 2007 Oct 18;50(21):5076-89. Epub 2007 Sep 15.
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| Neurokinin 1 receptor antagonists--current prospects.
The isolation of substance P (SP) in 1931, and the later discovery of its... | GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, | Curr Opin Drug Discov Devel. 2007 Sep;10(5):613-21. |
| From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists.
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1... | GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, | Bioorg Med Chem Lett. 2007 Apr 15;17(8):2254-9. Epub 2007 Jan 25.
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| Isoindolone derivatives, a new class of 5-HT2C antagonists: synthesis and biological evaluation.
Two independent approaches resulted in the identification of a series of... | GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, | Bioorg Med Chem Lett. 2007 Jan 15;17(2):428-33. Epub 2006 Oct 17.
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