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Recent Publications by GlaxoSmithKline Medicine Research Centre: |  | |
| Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
The hypothalamic peptides orexin-A and orexin-B are potent agonists of two... | GlaxoSmithKline Medicine Research Centre, Via A. Fleming, 4, 37135 Verona, | Bioorg Med Chem Lett. 2011 Sep 15;21(18):5562-7. Epub 2011 Jun 30.
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| A robust experimental protocol for pharmacological fMRI in rats and mice.
Pharmacological Magnetic Resonance Imaging (phMRI) methods have... | GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, | J Neurosci Methods. 2012 Feb 15;204(1):9-18. Epub 2011 Oct 28.
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| Escitalopram modulates neuron-remodelling proteins in a rat gene-environment interaction model of depression as revealed by proteomics. Part I: genetic background.
The wide-scale analysis of protein expression provides a powerful strategy... | Neurosciences CEDD, GlaxoSmithKline Medicine Research Centre, Verona, | Int J Neuropsychopharmacol. 2011 Jul;14(6):796-833. doi:
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| Escitalopram affects cytoskeleton and synaptic plasticity pathways in a rat gene-environment interaction model of depression as revealed by proteomics. Part II: environmental challenge.
Large-scale investigations aimed at elucidating the molecular mechanism of... | Neurosciences CEDD, GlaxoSmithKline Medicine Research Centre, Verona, | Int J Neuropsychopharmacol. 2011 Jul;14(6):834-55. doi:
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| Brain reinforcement system function is ghrelin dependent: studies in the rat using pharmacological fMRI and intracranial self-stimulation.
Ghrelin (GHR) is an orexigenic gut peptide that interacts with brain... | Behavioral Neuroscience Program, Department of Psychology, Texas A&M | Addict Biol. 2011 Oct 21. doi: 10.1111/j.1369-1600.2011.00392.x.
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