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Recent Publications by Biotica: |  | |
| Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
Cyclophilin inhibitors currently in clinical trials for hepatitis C virus... | Biotica Technology Ltd., Chesterford Research Park, Cambridge CB10 1XL, | Antimicrob Agents Chemother. 2011 May;55(5):1975-81. Epub 2011 Mar 7.
DOI Direct Link |
| Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
The macrocyclic polyketides FK506, FK520, and rapamycin are potent... | Biotica, Chesterford Research Park, Cambridge CB10 1XL, United Kingdom. | Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. Epub 2011 Mar 7.
DOI Direct Link |
| Glycosylation engineering of spinosyn analogues containing an L-olivose moiety.
Biosynthetic genes encoding proteins involved in the first steps of... | Biotica Technology Ltd, Chesterford Research Park, Cambridge, UK CB10 1XL. | Org Biomol Chem. 2009 Apr 21;7(8):1705-8. Epub 2009 Mar 12.
DOI Direct Link |
| Chapter 14. Biosynthesis of nonribosomal peptide precursors.
Nonribosomal peptides are natural products typically of bacterial and... | Biotica, Chesterford Research Park, Little Chesterford, Essex, United | Methods Enzymol. 2009;458:353-78.
DOI Direct Link |
| Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
The glycosylation of natural product scaffolds with highly modified... | Biotica Technology Ltd, Chesterford Research Park, Little Chesterford, | Org Biomol Chem. 2008 Sep 21;6(18):3315-27. Epub 2008 Jul 28.
DOI Direct Link |
Biotica Patents: |  |
| US Patent No. | Title |
| 8008318 | 39-desmethoxy derivatives of rapamycin |
| 7300942 | Production of polyketides and other natural products |
| 7198922 | Polyketides and their synthesis |
| 7183289 | 39-desmethoxyrapamycin, compositions and methods of use thereof |
| 7148045 | Hybrid polyketide synthases and novel loading domains |