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Recent Publications by Biotica: |  | |
| Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
The glycosylation of natural product scaffolds with highly modified... | Biotica Technology Ltd, Chesterford Research Park, Little Chesterford, | Org Biomol Chem. 2008 Sep 21;6(18):3315-27. Epub 2008 Jul 28.
DOI Direct Link |
| Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
A biosynthetic medicinal chemistry approach was applied to the... | Biotica Technology Limited, Chesterford Research Park, Nr. Saffron Walden, | J Med Chem. 2008 Sep 25;51(18):5494-7.
DOI Direct Link |
| Molecular characterization of macbecin as an Hsp90 inhibitor.
Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being... | Biotica Technology Limited, Chesterford Research Park, Essex CB10 1XL, | J Med Chem. 2008 May 8;51(9):2853-7. Epub 2008 Mar 22.
DOI Direct Link |
| Drug discovery beyond the 'rule-of-five'.
Although a very useful guideline for orally bioavailable small-molecule... | Biotica Technology Ltd., Chesterford Research Park, Little Chesterford nr | Curr Opin Biotechnol. 2007 Dec;18(6):478-88. Epub 2007 Nov 26.
DOI Direct Link |
| Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.
The production of epothilone mixtures is a direct consequence of the... | Biotica, Chesterford Research Park, Little Chesterford, Saffron Walden, | Org Biomol Chem. 2008 Feb 7;6(3):500-6. Epub 2007 Dec 12.
DOI Direct Link |
Biotica Patents: |  |
| US Patent No. | Title |
| 7390895 | Production of polyketides and other natural products |
| 6437151 | Erythromycins and process for their preparation |
| 6960453 | Hybrid polyketide synthases combining heterologous loading and extender modules |
| 7001747 | Nucleic acid molecules encoding modified polyketide synthases containing polylinkers and uses thereof |
| 7018808 | Polyketides and their synthesis and use |